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KMID : 0368820100490060653
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Journal of the Korean Neuropsychiatr Association
2010 Volume.49 No. 6 p.653 ~ p.656
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Two Cases of Reversible Neutropenia Associated with Olanzapine-Valproate Combination Treatment
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Kang Shi-Hyun
Oh Jung-Keun
Lee Jong-Il
Chang An-Gi
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Abstract
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The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the medication is not discontinued. We report two cases of reversible neutropenia associated with a olanzapine-valproate combination treatment. This report suggests that patients treated with the combination of olanzapine and valproate should be monitored for the occurrence of leukopenia and neutropenia.
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KEYWORD
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Neutropenia, Olanzapine, Valproate, Combination therapy
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